Beilstein J. Org. Chem.2023,19, 1259–1288, doi:10.3762/bjoc.19.94
interest in developing novel methodologies in this field of organic chemistry.
Keywords: alkylation; cross-dehydrogenationcoupling; ether; non-noble metals; Introduction
Since the 1970s, organic chemists have developed many selective cross-coupling methods for the construction of C–C bonds, such as the
synthesis of compounds with quaternary centers and natural products with high structural complexity.
In 2014, Li et al. reported a CuCl2-catalyzed cross-dehydrogenationcoupling reaction of C(sp3)–H bonds adjacent to an ether oxygen and the C(sp3)–H bonds at the α-position of a carbonyl functionality in the
attention. Todd et al. reported a method for the cross-dehydrogenationcoupling of isochroman C(sp3)–H bonds with anisole C(sp2)–H bonds using CuCl as a catalyst and DDQ as an oxidant (Scheme 11) [61]. However, this method is not ideal for tolerating substrates with electron-donating substituents (such as 1
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Graphical Abstract
Scheme 1:
Research progress of coupling reactions and active compounds containing α-C(sp3)-functionalized eth...